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Gaidhani, Sudesh
- Gut Microbiota:Metabolic Programmers as a Lead for Deciphering Ayurvedic Pharmacokinetics
Abstract Views :241 |
PDF Views:70
Authors
Anagha Ranade
1,
Shivani Gayakwad
2,
Shridhar Chougule
2,
Amey Shirolkar
3,
Sudesh Gaidhani
4,
Sharad D. Pawar
2
Affiliations
1 Department of Ayurveda, and Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
2 Department of Pharmacology, Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
3 National Center for Cell Science, Pune 411 007, IN
4 Central Council for Research in Ayurvedic Sciences, New Delhi 110 058, IN
1 Department of Ayurveda, and Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
2 Department of Pharmacology, Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
3 National Center for Cell Science, Pune 411 007, IN
4 Central Council for Research in Ayurvedic Sciences, New Delhi 110 058, IN
Source
Current Science, Vol 119, No 3 (2020), Pagination: 451-461Abstract
Gut microbiota has tremendous potential to influence human physiology in terms of health and disease. Factors like improper diet, lifestyle and stress contribute in development of dysbiosis. Ayurveda emphasizes on the importance of mahasrotasa (GIT system) and its homeostasis in maintenance of health. Pharmacokinetic principles of Ayurvedic pharmacology include Vipaka, commonly referred to as ‘postdigestive irreversible process’ which is closely associated with biotransformation of drugs caused by microbiota. There is evidence that the metabolism of polyphenols by the microbiota can influence their bioactivity. Consequently, inter-individual variation in microbial metabolism could have implications for health benefits of phytochemicals.Keywords
Ayurveda, Gut Microbiota, Pharmacokinetics, Metabolic Programmes.- Amelioration of Streptozotocin Induced Cytotoxicity by Mimosa pudica Root Extract - A Proteomic Based In-Vitro Study
Abstract Views :115 |
PDF Views:0
Authors
Pallavi S. Jamadagni
1,
Sharad D. Pawar
1,
Shrirang Jamadagni
1,
Shridhar Chougule
1,
Manish Wanjari
1,
Manish Gautam
2,
Sudesh Gaidhani
3,
Arun Gurav
1,
N. Shrikanth
3
Affiliations
1 Regional Ayurveda Research Institute, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Gandhi Bhavan Road, Kothrud, Pune - 411038, Maharashtra, IN
2 Assam Down Town University, Panikhaiti, Guwahati - 781026, Assam, IN
3 Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, 61-65, Institutional Area, Opposite Janakpuri D Block, New Delhi - 110058, IN
1 Regional Ayurveda Research Institute, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Gandhi Bhavan Road, Kothrud, Pune - 411038, Maharashtra, IN
2 Assam Down Town University, Panikhaiti, Guwahati - 781026, Assam, IN
3 Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, 61-65, Institutional Area, Opposite Janakpuri D Block, New Delhi - 110058, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 4 (2022), Pagination: 447-454Abstract
The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysis by LCMS. Mimosa pudica root powder extracts prevented Streptozotocin-induced cellular damage. Proteomics studies indicated both aqueous and hydro-alcoholic extracts of Mimosa pudica regulate proteins related to insulin secretion, glucose uptake, and insulin resistance with marked changes in proteins involved in insulin secretion. The study first time reports cytotoxicity of Mimosa pudica in RIN5F cells and explores protein expression after Mimosa pudica treatment. It was also observed that the abundance of Mimosine is more in Hydro-alcoholic extracts as compared to aqueous extracts.Keywords
LC-MS, Mimosa pudica, Proteomics, RIN5F.References
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